Overview
Top Medical Research Studies
In the open-label segment, patients took 150 mg of ubiquinol-10 daily for eight weeks, and both the participants and physicians knew who was receiving the supplement. The results were promising, suggesting improvements in various symptoms of CFS.
Following this, in the randomized trial, participants were assigned to either ubiquinol-10 or a placebo for 12 weeks, with neither the patients nor the doctors aware of who received which treatment. Outcomes showed that those taking ubiquinol-10 experienced significant benefits, reinforcing the notion that this supplement can positively influence CFS symptoms.
Overall, this study suggests that adding ubiquinol-10 to a treatment plan could be a helpful strategy for improving the lives of those dealing with chronic fatigue syndrome.
CoQ10 acts as a powerful antioxidant, playing an essential role in how our cells generate energy. By supplementing with CoQ10, studies suggest that patients may see improvements in overall quality of life, including reduced feelings of tiredness and enhanced performance during physical activities.
The evidence indicates a positive relationship between CoQ10 supplementation and decreased fatigue levels in those with chronic fatigue syndrome. By helping to minimize oxidative stress and protect mitochondrial function, CoQ10 might provide significant relief to sufferers of CFS, making it a promising candidate for future therapeutic strategies.
Overall, our findings suggest that coenzyme Q10 could offer a valuable option for managing chronic fatigue syndrome, providing hope for those looking for effective treatment approaches.
We recorded key health metrics, including blood pressure, CoQ10 blood levels, and echocardiographic measurements that assess both diastolic and systolic heart function. The participants were then given CoQ10 supplements, and we conducted follow-up evaluations to measure any changes.
The treatment resulted in promising enhancements across the board—eighty percent of hypertensive patients experienced lowered blood pressure, while all participants showed improved diastolic functioning. Moreover, more than half of the hypertensive group saw a reduction in myocardial thickness. However, while the results were favorable for various heart-related conditions, we noted that the information does not isolate the effects specifically for chronic fatigue syndrome, limiting our understanding of CoQ10’s isolated efficacy for this group.
Overall, the initial trial indicates that CoQ10 could potentially benefit heart function, which may help alleviate some symptoms associated with chronic fatigue syndrome, although more focused studies are needed to draw definitive conclusions for this specific condition.
Most Useful Reviews
Medical Researches
- All Researches
One group received the combined treatment, while the other group did not receive any treatment at all. Our focus was primarily on how well the treatment reduced fatigue, measured using the Fatigue Severity Scale (FSS).
The results were quite striking: a majority of those who received the treatment showed a significant reduction in fatigue compared to those who did not. In fact, over 53% of patients in the treatment group reported a complete response, whereas only a small fraction in the control group achieved similar results.
Overall, our findings indicate a positive effect of coenzyme Q10 and alpha lipoic acid on reducing chronic fatigue symptoms associated with chronic COVID. However, to validate these results further, we believe that a double-blind, placebo-controlled trial would be essential for confirming the effectiveness of this treatment approach.
Throughout the study, we measured key outcomes such as perceived fatigue, sleep quality, and overall health-related quality of life. We observed notable improvements in cognitive fatigue and health-related quality of life among those taking the CoQ10 and NADH supplement. Specifically, at the end of the treatment period, we noted significant reductions in fatigue levels and improvements in sleep efficiency at various checkpoints.
These findings suggest that coenzyme Q10, coupled with NADH, could serve as a promising option for managing ME/CFS symptoms. However, further research is necessary to confirm these benefits and to better understand how these compounds work in the body to alleviate fatigue and enhance overall well-being in those affected by this challenging condition.
In several well-conducted trials, participants receiving a combination of multiple micronutrients with coenzyme Q10 showed reduced oxidative stress. This was particularly noted in those experiencing chronic fatigue syndrome. Additionally, healthy individuals demonstrated increased cerebral blood flow, enhanced energy expenditure, and improved fat oxidation when supplemented.
Participants also reported less mental and physical fatigue and found improvements in their cognitive performance during demanding tasks. The collective findings suggest that bolstering our diets with these supplements can offer significant benefits, especially in regions where micronutrient deficiencies are prevalent, even among those who generally eat well.
Overall, this evidence underscores the potential of coenzyme Q10 when used alongside other micronutrients to help improve nutritional status, energy metabolism, and subjective wellbeing in individuals facing chronic fatigue syndrome.
In the open-label segment, patients took 150 mg of ubiquinol-10 daily for eight weeks, and both the participants and physicians knew who was receiving the supplement. The results were promising, suggesting improvements in various symptoms of CFS.
Following this, in the randomized trial, participants were assigned to either ubiquinol-10 or a placebo for 12 weeks, with neither the patients nor the doctors aware of who received which treatment. Outcomes showed that those taking ubiquinol-10 experienced significant benefits, reinforcing the notion that this supplement can positively influence CFS symptoms.
Overall, this study suggests that adding ubiquinol-10 to a treatment plan could be a helpful strategy for improving the lives of those dealing with chronic fatigue syndrome.
Our primary focus was to measure the effect on age-predicted maximum heart rate (max HR) during exercise tests. Alongside this, we also looked at secondary factors including levels of fatigue, pain, and sleep quality. After the eight-week period, we found that individuals who took the CoQ10 and NADH combination showed a reduction in max HR during the cycle ergometer test. Additionally, they reported improvements in fatigue levels.
These results are promising as they suggest that this combination could be safe and potentially effective for reducing both heart rate responses to exertion and overall fatigue in CFS patients. However, we recognize the need for larger controlled trials to further validate these findings before drawing definitive conclusions.
User Reviews
- All Reviews
- Positive Reviews
- Negative Reviews
Frequently Asked Questions
Chronic Fatigue Syndrome (CFS), also known as Myalgic Encephalomyelitis (ME), is a complex and debilitating condition characterized by profound fatigue that doesn’t improve with rest and worsens with physical or mental activity. This crippling fatigue is often accompanied by a variety of symptoms, including sleep disturbances, cognitive difficulties, muscle pain, and joint pain. Unlike typical tiredness, the fatigue experienced in CFS is long-lasting, and it can significantly hinder everyday activities and overall quality of life.
The precise cause of CFS remains unknown, but it is believed to be influenced by a combination of genetic, environmental, immunological, and psychological factors. Diagnosis primarily relies on a careful assessment of symptoms, as there are no definitive laboratory tests available. Treatment options focus on symptom management and may include lifestyle changes, physical therapy, medication for pain management, and cognitive behavioral therapy. Given the complexity and variability of the condition, individuals with CFS should consult healthcare professionals who specialize in this area to develop personalized management strategies.
Coenzyme Q10, often abbreviated as CoQ10, is a naturally occurring antioxidant that is found in the cells of the body. It plays a crucial role in the production of energy within mitochondria, which are the powerhouses of our cells. CoQ10 is important for maintaining cellular energy levels and overall health, as it assists in the conversion of food into energy. Additionally, it helps protect cells from oxidative damage, which is linked to various conditions such as heart disease and aging.
As a dietary supplement, CoQ10 is popular for its potential benefits, including promoting heart health, improving energy levels, and supporting cognitive function. It's particularly beneficial for individuals who are taking statin medications, as these drugs can lower natural CoQ10 levels in the body. While more research is needed to determine its efficacy fully, many users have reported positive experiences. If you’re considering adding CoQ10 to your supplement routine, it’s best to consult with a healthcare professional to determine the appropriate dosage and ensure it fits your health needs.
Based on user reviews, the timeframe for experiencing results from Coenzyme Q10 varies from just a few days to several months, indicating a range of responses among individuals. Many users have reported feeling a noticeable increase in energy levels after just two weeks of consistent use. For instance, one reviewer experienced a significant improvement in energy after 14 days of daily intake (Read Review). Another user noted enhanced energy and sharpness within just three weeks (Read Review).
However, some users have mentioned needing a longer commitment to see substantial benefits, with one stating they achieved better stamina after eight years of use (Read Review). While immediate effects such as increased energy may be observed by some, others have found that a multi-week or even multi-month routine is necessary for optimal results. Therefore, if you are considering CoQ10 for Chronic Fatigue Syndrome, set a timeframe of a few weeks to a couple of months to assess its efficacy for your specific condition.
Coenzyme Q10 (CoQ10) has garnered attention in the realm of Chronic Fatigue Syndrome (CFS) for its potential benefits. Several studies have explored its role in alleviating CFS symptoms, presenting some promising, though mixed, results. For instance, a study combining CoQ10 with selenium showed significant improvements in fatigue and overall quality of life in individuals with CFS [3]. Meanwhile, another controlled trial combining CoQ10 with NADH indicated noticeable reductions in cognitive fatigue and enhancements in health-related quality of life [4]. However, it's worth noting that various trials suffered from methodological issues, such as small sample sizes and mixed supplement approaches, which complicate the overall efficacy assessment of CoQ10 [1].
Despite some positive findings, comprehensive evaluations have pointed towards insufficient evidence supporting the standalone effectiveness of CoQ10 for CFS relief. For instance, a systematic review concluded that while CoQ10 could contribute to symptom management, clearer and more targeted research is needed to determine its specific benefits [6]. Therefore, while CoQ10 shows potential as part of a broader treatment strategy for CFS, anyone considering this supplement should consult healthcare professionals and refer to ongoing research for the latest findings.
Users report varying degrees of improvement in symptoms associated with fatigue and energy levels after taking Coenzyme Q10. Many individuals have experienced a significant surge in energy, often within a couple of weeks or months. For instance, one user mentioned a substantial increase in energy levels after just two weeks of consistent use, allowing them to wake up without feelings of weakness (Read Review). Similarly, another reviewer noted that after a couple of months of taking CoQ10, they found it easier to get up in the mornings and felt rejuvenated post-training (Read Review).
Additionally, some users highlighted improvements in cognitive function and overall vitality. One individual with chronic fatigue syndrome reported feeling energetic enough to cook despite fatigue, with an enhanced sense of clarity and improved complexion after three weeks on the supplement (Read Review). However, it's important to note that individual results can vary significantly; some have taken up to eight years to notice their stamina increase, and others recommend combining CoQ10 with additional supplements for optimal results (Read Review). Overall, while many users found CoQ10 beneficial for alleviating fatigue and boosting energy levels, the effectiveness and timeframe for improvements can differ greatly among individuals.
Users report varying experiences when it comes to combining Coenzyme Q10 with other supplements for managing Chronic Fatigue Syndrome. Many have found that taking CoQ10 alongside omega-3 fatty acids and vitamin D3 yields positive results. For instance, one reviewer noted that this combination significantly improved their overall health and alleviated symptoms such as leg numbness during long drives (Read Review). Additionally, some users mentioned incorporating other supplements like vitamin B, D, and iron, which they believe supports their health and enhances the effects of CoQ10 (Read Review).
Moreover, certain reviewers emphasized the synergistic effects of taking CoQ10 with collagen, claiming it improved both energy levels and joint health, which can often be impacted alongside chronic fatigue issues (Read Review). While individual responses may vary, many attribute their improved energy and stamina to this combination of supplements, indicating that for those battling chronic fatigue, a multi-supplement approach might be beneficial. Overall, it appears that several users advocate for incorporating CoQ10 into a broader supplement regimen to maximize its effectiveness against chronic fatigue symptoms.
While research on Coenzyme Q10 (CoQ10) for Chronic Fatigue Syndrome (CFS) presents promising possibilities, determining an optimal dosage is somewhat complex. One study indicated that a combination of CoQ10 (400 mg) and selenium over eight weeks led to significant improvements in fatigue and quality of life among participants [3]. Additionally, a randomized trial showed that participants taking 200 mg of CoQ10 daily, alongside NADH, also reported notable reductions in fatigue levels [4].
However, results vary across studies, and the need for more rigorous, large-scale trials is crucial to establish a clearer understanding of CoQ10's efficacy as a standalone treatment for CFS. Although there are reports of benefits associated with CoQ10, such as improvements in oxidant balance and antioxidant capacity [3], it remains important to exercise caution and consult healthcare providers to tailor supplementation to individual needs. Overall, while clinical evidence points to potential benefits at doses of 200 mg or higher, further investigation is necessary to finalize recommendations for optimal dosing specifically for CFS.
After this eight-week period, we observed significant improvements in fatigue and overall quality of life. Participants reported feeling better, which is always encouraging. In terms of oxidative stress, we noticed a boost in total antioxidant capacity and a reduction in harmful lipoperoxide levels, both suggesting a positive shift in the body’s oxidative balance. Interestingly, although inflammatory markers showed a decrease, some important biomarkers remained unchanged.
This exploration into long-term supplementation indicates that CoQ10 and selenium may work together beneficially, providing hope for those grappling with CFS. However, we should note that while improvements were there, the effects were not uniform across all measures. It provides a valuable foundation for further research in this area.
Throughout the study, we measured key outcomes such as perceived fatigue, sleep quality, and overall health-related quality of life. We observed notable improvements in cognitive fatigue and health-related quality of life among those taking the CoQ10 and NADH supplement. Specifically, at the end of the treatment period, we noted significant reductions in fatigue levels and improvements in sleep efficiency at various checkpoints.
These findings suggest that coenzyme Q10, coupled with NADH, could serve as a promising option for managing ME/CFS symptoms. However, further research is necessary to confirm these benefits and to better understand how these compounds work in the body to alleviate fatigue and enhance overall well-being in those affected by this challenging condition.
Among the fourteen studies reviewed, some reported positive outcomes with CoQ10, especially when combined with other treatments. However, the variations in study designs and the presence of methodological issues, like small sample sizes, made it difficult to draw any concrete conclusions about its efficacy.
While inconsistent results surfaced regarding enhancements in energy levels, we also noted several adverse effects reported by participants, such as nausea and insomnia. Thus, while CoQ10 shows promise, we need more rigorous research to better understand its potential benefits for CFS.
Seventeen studies met our criteria for inclusion, each investigating various dietary modifications and nutritional supplements. Among them, coenzyme Q10 was evaluated in conjunction with another supplement, nicotinamide adenine dinucleotide hydride (NADH). While some improvements in fatigue were noted with this combined approach, we need to be clear that the evidence did not strongly support the isolated effectiveness of coenzyme Q10 alone for CFS symptoms.
Overall, we found insufficient evidence to confirm that coenzyme Q10, on its own or in combination, offers significant therapeutic benefits for patients with chronic fatigue syndrome. Hence, more targeted research focusing on CFS populations is needed to paint a clearer picture of how coenzyme Q10 and other nutritional interventions might fit into treatment strategies.
References
- Dorczok MC, Mittmann G, Mossaheb N, Schrank B, Bartova L, et al. Dietary Supplementation for Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systematic Review. Nutrients. 2025;17. doi:10.3390/nu17030475
- Barletta MA, Marino G, Spagnolo B, Bianchi FP, Falappone PCF, et al. Coenzyme Q10 + alpha lipoic acid for chronic COVID syndrome. Clin Exp Med. 2023;23:667. doi:10.1007/s10238-022-00871-8
- Castro-Marrero J, Domingo JC, Cordobilla B, Ferrer R, Giralt M, et al. Does Coenzyme Q10 Plus Selenium Supplementation Ameliorate Clinical Outcomes by Modulating Oxidative Stress and Inflammation in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?. Antioxid Redox Signal. 2022;36:729. doi:10.1089/ars.2022.0018
- Castro-Marrero J, Segundo MJ, Lacasa M, Martinez-Martinez A, Sentañes RS, et al. Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2021;13. doi:10.3390/nu13082658
- Maggini S, Óvári V, Ferreres Giménez I, Pueyo Alamán MG. Benefits of micronutrient supplementation on nutritional status, energy metabolism, and subjective wellbeing. Nutr Hosp. 2021;38:3. doi:10.20960/nh.03788
- Campagnolo N, Johnston S, Collatz A, Staines D, Marshall-Gradisnik S. Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgic encephalomyelitis: a systematic review. J Hum Nutr Diet. 2017;30:247. doi:10.1111/jhn.12435
- Fukuda S, Nojima J, Kajimoto O, Yamaguti K, Nakatomi Y, et al. Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome. Biofactors. 2016;42:431. doi:10.1002/biof.1293
- Castro-Marrero J, Sáez-Francàs N, Segundo MJ, Calvo N, Faro M, et al. Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome - A randomized, controlled, double-blind trial. Clin Nutr. 2016;35:826. doi:10.1016/j.clnu.2015.07.010
- Castro-Marrero J, Cordero MD, Segundo MJ, Sáez-Francàs N, Calvo N, et al. Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome?. Antioxid Redox Signal. 2015;22:679. doi:10.1089/ars.2014.6181
- Nicolson GL. Mitochondrial dysfunction and chronic disease: treatment with natural supplements. Altern Ther Health Med. 2014;20 Suppl 1:18.
- Cordero MD, Alcocer-Gómez E, Culic O, Carrión AM, de Miguel M, et al. NLRP3 inflammasome is activated in fibromyalgia: the effect of coenzyme Q10. Antioxid Redox Signal. 2014;20:1169. doi:10.1089/ars.2013.5198
- Morris G, Anderson G, Berk M, Maes M. Coenzyme Q10 depletion in medical and neuropsychiatric disorders: potential repercussions and therapeutic implications. Mol Neurobiol. 2013;48:883. doi:10.1007/s12035-013-8477-8
- Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, et al. Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder. Neuro Endocrinol Lett. 2009;30:470.
- Bentler SE, Hartz AJ, Kuhn EM. Prospective observational study of treatments for unexplained chronic fatigue. J Clin Psychiatry. 2005;66:625.
- Langsjoen PH, Langsjoen PH, Folkers K. Isolated diastolic dysfunction of the myocardium and its response to CoQ10 treatment. Clin Investig. 1993;71:S140.
